机读格式显示(MARC)

• 000 01847cam a2200277 i 4500

• 001 0000844612

• 005 20251106152900.0

• 008 250930s2010 enk b 001 0 eng d

• 020 __ |a 9781441938046 |q paperback

• 040 __ |a CNPIEC |b eng |c CNPIEC |e rda

• 050 _4 |a QH603.L9

• 082 04 |a 571.6/55 |2 23

• 090 __ |a Q24/X3

• 093 __ |a Q24 |2 4

• 100 1_ |a Saftig, Paul, |e author.

• 245 10 |a Lysosomes / |c Paul Saftig.

• 260 __ |a New York, N.Y. : |b Springer, |c 2010.

• 300 __ |a 197 pages ; |c 24 cm

• 336 __ |a text |2 rdacontent

• 337 __ |a unmediated |2 rdamedia

• 338 __ |a volume |2 rdacarrier

• 490 0_ |a Medical intelligence unit

• 504 __ |a Includes bibliographical references and index.

• 520 __ |a Lysosomes are membrane-surrounded organelles which are present in all animal cells. The importance of this organelle is underlined by an increasing number of human diseases, which are associated with an impaired function of the lysosomal compartment. This book summarizes the current state-of-the art knowledge about this unique organelle. It addresses the biogenesis of this compartment, the transport of lysosomal proteins, the role of the lysosomal membrane in lysosomal stability and transport, the function of lysosomal proteases and hydrolases, lysosomal storage disorders, and new concepts on how to treat these diseases. In addition to these classical topics, new insights into lysosomal functions are covered by chapters dealing with specialized lysosomes involved in bone resorption and plasma membrane repair, the lysosomal transciptome, and proteome and the emerging role of lysosomes in special forms of autophagy. This book will provide readers with a comprehensive overview into how this fascinating organelle works and how research in the field is developing.

• 650 _0 |a Lysosomes.

• 650 _0 |a Biological transport.