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题名/责任者:

Chemotaxis modeling of autoimmune inflammation : PDE computer analysis in R / William E. Schiesser.

版本说明:

First edition.

出版发行项:

Boca Raton : CRC Press, 2024.

ISBN:

9781032317649

ISBN:

1032317647

载体形态项:

vii, 143 pages : illustrations ; 25 cm

个人责任者:

Schiesser, W. E., author.

论题主题:

Inflammation-Immunological aspects.

论题主题:

Chemotaxis-Immunology.

论题主题:

Chemotaxis-Models.

论题主题:

Autoimmune diseases-Pathophysiology.

中图法分类号:

R593.2

一般附注:

Originally published: 2022.

书目附注:

Includes bibliographical references and index.

摘要附注:

"This book is directed to the computer-based modeling of chemotaxis inflammation, typically resulting from an infection by a pathogen (e.g., bacteria, viruses). The spatiotemporal analysis is based on a model of three partial differential equations (PDEs). The three PDE model is coded (programmed) as a set of routines in R, a quality, open source, scientific programming system. The numerical integration (solution) of the PDEs is by the method of lines (MOL). The three PDE model can be used for computer-based experimentation, for example, parameter variation and changes in the model equations of alternate models, to enhance a quantitative understanding of a postulated inflammation. This experimentation is illustrated by chapters pertaining to (1) the computation and display of the PDE time derivatives, (2) the RHS terms of the PDEs with emphasis on the chemotaxis terms, (3) parameter variations to demonstrate parameter effects and sensitivities and (4) additional items in the PDEs to include PDE coupling and extensions of the basic PDE model. The book has particular relevance to the corona virus pandemic since long-Covid neurological impairment may be the result of brain inflammation"--

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